View our webinar "Parkinson’s-in-a-Dish: Advances using Donor-derived Models in 2D and 3D".

Parkinson’s disease (PD) is a debilitating neurodegenerative disease defined by loss of midbrain dopaminergic neurons and motor dysfunction. Risk of developing PD is associated with myriad of genetic mutations, thus, greatly increasing the need for donor-derived cellular models for discovering gene-specific or general compounds to combat PD. 

You won’t want to miss the discussion between FUJIFILM Cellular Dynamics' Ali Fathi, PhD and Coby Carlson, PhD as they share their knowledge of induced pluripotent stem cells (iPSC)-derived dopaminergic neurons for the acceleration of biopharma drug discovery research for PD, specifically 2D and 3D cellular models utilizing donor-derived dopaminergic neurons.

During this webinar, you will learn:

 

• Importance of donor-derived models for drug discovery 

• Characterization of patient LRRK2 G2019S and GBA N370S iCell DopaNeurons

• Creation of iCell NeuroSpheres for PD Modeling

• New 3D application for iCell DopaNeurons

 

Speakers:

Ali Fathi, PhD, Senior Scientist, FUJIFILM Cellular Dynamics

Presentation Title: High Throughput Screening of Compounds for Parkinson’s Disease using LRRK2 G2019S and GBA N370S Donor-derived Dopaminergic Neurons

 Ali Fathi, PhD

Ali Fathi is a Senior Scientist at FUJIFILM Cellular Dynamics. He received his PhD in Developmental Biology from the University of Science and Culture in Tehran, followed by a postdoctoral position in the lab of Su-Chun Zhang at the University of Wisconsin. Ali’s research has focused on neurodegenerative disease modeling using human induced pluripotent stem cell-derived neurons. His experience and knowledge are applied to develop and characterize iPSC-derived healthy and disease-relevant neuronal cell types at FUJIFILM Cellular Dynamics. 

 

 

Coby Carlson, PhD, Director, Innovation and New Technology, FUJIFILM Cellular Dynamics

Presentation Title: iCell® Neurospheres: A Customizable 3D System for Disease Modeling

Coby Carlson, PhD

Coby Carlson is the Director, Innovation and New Technology at FUJIFILM Cellular Dynamics where his team focuses on advancing iPSC-derived cell use for drug screening, toxicity testing, and disease modeling. He joined the company in 2012 and has extensive experience applying iCell neural cell types in 2D and 3D co-cultures to both monitor neural activity, using MEA or calcium imaging, and characterize the health and function of wild-type and diseased iPSC-derived neurons. Coby received his PhD from the University of Utah followed by a postdoctoral fellowship at the University of Wisconsin – Madison.