iCell DopaNeurons

Access functional and reliable human dopaminergic neurons based on technology licensed and adapted from the Lorenz Studer lab (Memorial Sloan Kettering). Derived from induced pluripotent stem cells (iPSCs), iCell^® DopaNeurons incorporate highly relevant morphological and phenotypic features of primary human midbrain floor plate-derived dopaminergic neurons. These iPSC-derived dopaminergic neurons exhibit complete regional specificity for optimal function, providing a robust and versatile in vitro model for studying dopaminergic cells in health and disease, neurotoxicity, and regenerative medicine.

• Consistent excellence Highly pure populations of >80% tyrosine hydroxylase-positive (THpos) midbrain iPSC-derived dopaminergic neurons ensure reproducible and scalable results.
• Human relevance iCell DopaNeurons express key transcription factors and markers, including Lmx1, FoxA2, Nurr1, and tyrosine hydroxylase.
• Physiological function Like primary human dopaminergic cells, iCell DopaNeurons exhibit spontaneous and evoked action potentials and are capable of dopamine release and uptake.
• Versatile functionality iPSC-derived dopaminergic neurons enable the study of neurological development and disease by faithfully capturing neurite outgrowth and retraction, mitophagy, and calcium signaling.
• Optimal efficiency iCell DopaNeurons enable more experiments in less time by arriving fully differentiated, forming branched networks within 2-3 days, and displaying stable morphology and viability for ≥14 days.