Epilepsy Cell Models

Reliable in vitro epilepsy models are essential for understanding seizure biology and advancing anti-epileptic drug discovery.

Our induced pluripotent stem cell (iPSC)-derived GABAergic neurons carry clinically relevant mutations: SCN1A heterozygous knockout (HZ KO), a leading genetic cause of Dravet Syndrome, and KCNT1 (P924L). Multielectrode array (MEA) validation confirms key epileptic phenotypes, while phenotypically healthy isogenic controls enable precise interpretation of mutation-specific effects.

• Disease relevance KCNT1 (P924L) and SCN1A HZ KO lines model distinct, clinically relevant epilepsy genotypes with MEA-validated seizure-like phenotypes.
• Dependable quality Each epilepsy model delivers >95% pure neuronal populations with consistent lot-to-lot GABA phenotypes and cell viability for reproducible results.
• Advanced culture Co-culture with iCell^® GlutaNeurons and tri-culture with iCell^® Astrocytes enhances network-level neural activity, increasing physiological relevance.
• Simple implementation Each in vitro epilepsy model is available as cells only or a complete kit, cryopreserved and ready to use from thaw.