Alzheimer's Disease Cell Line Models

Robust, genetically defined Alzheimer's disease cell line models are essential for advancing neurodegeneration research and drug discovery.

Spanning neuronal and microglial cell types, our human induced pluripotent stem cell (iPSC)-derived Alzheimer's disease cell lines capture key risk-associated and protective genetic variants, including in APOE, APP, and TREM2. Isogenic healthy controls enable precise interpretation of mutation-specific effects, and every line is fully differentiated—simply thaw and use.

• Disease relevance Each Alzheimer's disease cell line model reflects a clinically relevant genotype, from high-risk APOE E4/E4 to protective APP A673T.
• Consistent quality Stringent quality control ensures reliable purity and performance across every batch of these Alzheimer’s cell culture lines.
• Broad applications From mechanistic studies to drug discovery and screening, these Alzheimer's cell culture models fuel diverse research at scale.
• Microglial models TREM2 microglia and other Alzheimer's microglial variants capture critical disease characteristics, including impaired phagocytosis.
• Flexible formats Each Alzheimer's disease cell line is available as cells only or a complete kit, cryopreserved and ready to use from thaw.