iCell GABANeurons

Discover high-quality, relevant human in vitro models for the study of GABAergic neurons in basic and preclinical research. iCell^® GABANeurons are mixed populations of human cortical neurons derived from induced pluripotent stem cells (iPSCs). These iPSC-derived cortical neurons overcome the limitations of simplified human brain models, such as transformed cell lines, providing a robust, reliable, and scalable model for drug discovery, neurotoxicity testing, and health and disease research.

• Consistent excellence Homogenous populations of >95% human cortical neurons, primarily consisting of GABAergic neurons, ensure reproducible results with every batch.
• Functional capabilities Like primary human cortical neurons, iCell GABANeurons exhibit spontaneous electrical activity, allowing early detection of drug-induced changes to neuronal electrophysiology and biochemistry.
• Accurate morphology Terminally differentiated from human iPSCs, iCell GABANeurons exhibit typical cortical neuron morphology with branching neurites.
• Human relevance iCell GABANeurons have functional synapses and express relevant neurological therapeutic targets and pathways, including vGAT and vGLUT2.
• Versatile functionality From Alzheimer’s disease to autism and infectious diseases to neurotoxicity, iPSC-derived cortical neurons have extensive applicability in neurological research.
• Long-term viability iCell GABANeurons are transcriptionally and phenotypically stable for extended periods, enabling studies of ≥14 days.