Drive Preclinical Insights with iPSC-based Parkinson’s Models
Developing effective treatments for Parkinson’s disease requires translational models that reflect key disease features, including dopaminergic neuronal degeneration and alpha-synuclein (α-syn) accumulation. Its multifactorial nature makes the creation of predictive Parkinson’s disease models particularly challenging.
Induced pluripotent stem cell (iPSC)-derived dopaminergic neurons are advancing Parkinson’s disease research. Our reliable and scalable iPSC-based Parkinson’s models, including patient-derived and engineered iCell® DopaNeurons, offer consistent “Parkinson’s-in-a-dish” systems to support research and drug screening.
Achieve Consistency with Engineered Parkinson’s Models
Power biologically relevant and reproducible research
Overcome sample scarcity and inter-patient variability with Parkinson’s disease models engineered from apparently healthy normal (AHN) human iPSCs. Our gene editing expertise provides robust, off-the-shelf dopaminergic neurons with disease-associated mutations and isogenic controls, fueling reliable, scalable Parkinson’s research.
Investigate the impact of SNCA A53T on Parkinson’s Pathology
SNCA A53T is a low-frequency, highly penetrant mutation that makes α-syn more prone to aggregate and accumulate in neurons—a hallmark of Parkinson’s disease pathology.
SNCA Cell Lines:
Discover Clinically Relevant Patient-Derived Parkinson’s Models
Investigate high-risk mutations in a reliable in vitro model
Access dopaminergic neurons differentiated from iPSCs obtained through the Parkinson’s Progression Markers Initiative (PPMI), launched by the Michael J. Fox Foundation.
Choose from iCell DopaNeurons with Parkinson’s-associated mutations or mutation-corrected controls, all backed by comprehensive clinical, imaging, and multi-omic data.
α-syn accumulation is increased in GBA N370S, LRRK2 G2019S, and SNCA A53T iCell DopaNeurons compared to AHN iCell DopaNeurons. Measured using Human α-Synuclein Assay from Meso Scale Discovery (MSD).
Representative images and calcium oscillation traces of iCell NeuroSpheres formed using AHN, patient-derived (GBA N370S and LRRK2 G2019S), or engineered (SNCA A53T) iCell DopaNeurons. Data shows differing calcium activity patterns between the control and disease-phenotype neurospheres.
Enhance Physiological Relevance with 3D Neural Spheroids
Boost the predictive power of your Parkinson’s disease research by incorporating iCell NeuroSpheres, versatile 3D in vitro models designed for disease research and drug discovery.
Combine patient-derived or engineered iCell DopaNeurons with iCell Astrocytes to generate advanced Parkinson’s disease models amenable to calcium imaging and other high-throughput applications.
- Simplify model generation with off-the-shelf neural cell lines
- Incorporate Parkinson’s disease iCell DopaNeurons for translational disease modeling
- Ensure consistency with uniform sphere size and controlled cell type ratios
- Fuel high-throughput research with one sphere per well in a 384-well format
Need a custom iPSC-derived Parkinson's disease model?
Our team of experts is ready to help you generate custom Parkinson’s models using cells from the PPMI Parkinson's iPSC Bank or your own donor source.
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