Fuel Discovery with iPSC-based Alzheimer’s Disease Cell Line Models
Biologically relevant in vitro Alzheimer's disease models will improve our understanding of disease mechanisms and accelerate drug development. Yet, incorporating the disease complexity and genetic risk factors needed to create relevant, predictive Alzheimer’s disease models remains challenging.
Using induced pluripotent stem cell (iPSC) technology, we have developed reliable, scalable, and translational human Alzheimer’s disease cell lines. Choose from patient-derived models, engineered iPSCs, or induced Alzheimer’s disease neurons to create mono- or multi-cellular “Alzheimer's-in-a-dish” models.
Engineer Precise Alzheimer’s Disease Cell Lines
Access consistent models with disease-specific mutations
Eliminate the challenges of inter-patient variability and patient sample scarcity with disease models engineered from apparently healthy normal (AHN) iPSCs. Our gene editing expertise ensures robust and reproducible Alzheimer's disease cell line models and isogenic controls, with off-the-shelf iCell® neurons and microglia available.
Explore Robust Engineered Alzheimer’s Disease Models
Investigate the functional consequences of TREM2 variants
TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a microglial immune receptor with rare variants linked to increased Alzheimer’s risk.
TREM2 Cell Lines:
Explore the impact of APOE genotype on Alzheimer’s risk
The allelic composition of APOE (Apolipoprotein E) influences the risk of developing Alzheimer’s.
Compared to the common E3 allele, E2 confers protection, and E4 increases risk.
APOE Cell Lines:
Uncover APP’s pathological or protective mechanisms
Genetic mutations in APP (Amyloid Precursor Protein) contribute to the early onset of (A673V variant) or protection against (A673T variant) Alzheimer’s.
APP Cell Lines:
Access Relevant Patient-Derived Alzheimer’s Disease Cell Lines
Interrogate mechanisms and identify therapeutic targets
Microglia play critical roles in neurodegeneration, expressing several genes linked to increased Alzheimer’s risk.
Our readily available patient-derived Alzheimer’s disease microglia are generated from donor iPSCs with relevant genotypes and phenotypes.
Browse Microglial Alzheimer’s Models
Choose from phenotypically AHN or symptomatic Alzheimer’s disease microglia.
Discover Robust and Reliable Induced Alzheimer's Disease Models
Investigate pathological mechanisms and fuel drug discovery
The accumulation of amyloid beta (Aβ) in the cortex is a key component of Alzheimer’s disease pathophysiology.
Adding Aβ1-42 peptide to iCell GABANeurons generates consistent inducible Alzheimer’s disease cell line models to power scalable, high-throughput studies.
Explore GABANeurons Alzheimer’s Models
- Produce measurable levels of Tau and Aβ proteins.
- Express stable and reproducible levels of total Tau and Aβ.
- Enable high-throughput screening of neuroprotective compounds.
- Explore healthy isogenic controls in the absence of Aβ1-42.
Need a custom Alzheimer’s disease cell line?
Our team of experts is ready to help you generate custom models to fuel Alzheimer’s research with your donor cells or our alternate neural cell types.
Elevate Alzheimer’s Research with Reliable Assays and Reagents
Detect and quantify Aβ and Tau with antibodies and ELISA kits from Fujifilm.
Access monoclonal antibodies qualified for a range of detection methods including Western blot, ICC/IHC, immunoprecipitation, and ELISA.
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