iCell GABANeurons AD APOE E2/E2, 01434

Apolipoprotein E gene (APOE) is a cholesterol-carrying protein involved in neuronal growth, synaptic maturation, and cellular repair. The composition of APOE, which has three polymorphic alleles (E2, E3, and E4), is a major risk factor Alzheimer’s disease (AD). While APOE E4/E4 has been shown to increase risk of AD, research suggests APOE E2/E2 can confer protection against developing AD. Early research indicates E2 directly impacts amyloid-beta (Aβ) processing (reducing production and deposition) as well as having non-AD related effects on neuronal health via modulating oxidative stress and glucose metabolism pathways.

iCell GABANeurons AD APOE E2/E2 were developed as a cellular model to investigate mechanisms of neuronal protection and discovery of potential therapeutics against AD. The APOE E2/E2 cell line was engineered from the isogenic parental APOE E3/E3 induced pluripotent stem cell line, followed by differentiation into cortical neurons that exhibit a majority GABAergic phenotype.

Features of iCell GABANeurons APOE 2/2:

• >95% pure neuronal population with a majority of GABAergic (inhibitory) neurons
• Consistent lot-to-lot GABA phenotypes and cell viability
• Isogenic iCell GABANeurons, 01434 are available.

View all Alzheimer’s disease cell models here.