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iCell GABANeurons AD APOE E2/E2, 01434
Human iPSC-derived GABA neurons from a Caucasian female (age <18) with an Alzheimer's disease (AD) phenotype (genotype: APOE E2/E2), differentiated from fibroblast-derived iPSCs.
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Kits
- 1 vial Cryopreserved iCell GABANeurons AD APOE E2/E2, 01434
- 100 ml Neural Base Medium 1
- 2 ml Neural Supplement A
- User’s Guide
genetic status
Quantity (Cells Per Vials)
Catalog #
Catalog #:
Alzheimer's Disease differentiated from human iPS cells, frozen
From
$2,599.00
Cells Only
- 1 vial Cryopreserved iCell GABANeurons AD APOE E2/E2, 01434
- User’s Guide
genetic status
Quantity (Cells Per Vials)
Catalog #
Catalog #:
Alzheimer's Disease differentiated from human iPS cells, frozen
From
$2,499.00
Product Overview
Apolipoprotein E gene (APOE) is a cholesterol-carrying protein involved in neuronal growth, synaptic maturation, and cellular repair. The composition of APOE, which has three polymorphic alleles (E2, E3, and E4), is a major risk factor Alzheimer’s disease (AD). While APOE E4/E4 has been shown to increase risk of AD, research suggests APOE E2/E2 can confer protection against developing AD. Early research indicates E2 directly impacts amyloid-beta (Aβ) processing (reducing production and deposition) as well as having non-AD related effects on neuronal health via modulating oxidative stress and glucose metabolism pathways.
iCell GABANeurons AD APOE E2/E2 were developed as a cellular model to investigate mechanisms of neuronal protection and discovery of potential therapeutics against AD. The APOE E2/E2 cell line was engineered from the isogenic parental APOE E3/E3 induced pluripotent stem cell line, followed by differentiation into cortical neurons that exhibit a majority GABAergic phenotype.
Features of iCell GABANeurons APOE 2/2:
- >95% pure neuronal population with a majority of GABAergic (inhibitory) neurons
- Consistent lot-to-lot GABA phenotypes and cell viability
- Isogenic iCell GABANeurons, 01434 are available.
View all Alzheimer’s disease cell models here.
Components:
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Need Help With This Product?
Our specialists are here to help you find the best product for your application.
Our regular business hours are 9:00am to 5:00pm Central Time (USA)
Technical Docs
USER DOCS
Biosafety Document
APOE 2/2 iCell Products Biosafety Document
Product Highlights
Applications:
- Alzheimer’s disease modeling
- Drug target and therapeutic screening
- Tri-culture with iCell Microglia and iCell Astrocytes