Boost Predictive Safety Pharmacology & Cytotoxicity Testing
The industry needs better models. Despite integrating in silico, animal, and in vitro toxicity testing, the limited biological relevance of traditional models is leading to increased late-stage drug attrition and market withdrawals.
iCell® products, differentiated from human-derived induced pluripotent stem cells (iPSCs), are reliable and translational. They improve predictive safety pharmacology and cytotoxicity testing, ultimately enhancing patient safety and cutting costs.
Drive Translational and Consistent In Vitro Toxicity Testing
Accurately predict human outcomes
FUJIFILM CDI’s readily available iPSC-derived cell lines closely mimic human biology, providing a solution that overcomes the challenges of poor relevance, reproducibility, and accessibility.
By addressing these common pitfalls of preclinical toxicology screening and safety pharmacology systems, iCell models reduce the risk of adverse effects and safety-related failures.
Enhance Translatability with iPSCs for Toxicology Screening
Verified predictive model of drug-induced arrhythmias
iCell Cardiomyocytes are the gold standard, having been evaluated as part of the comprehensive in vitro proarrhythmia assay (CiPA) initiative.
- Highly pure populations of >95% cardiomyocytes
- Industry-leading number of peer-reviewed publications
- Disease models available, including dilated cardiomyopathy
- Optimized post-thaw recovery and ≤2 weeks viability
Highly-characterized for drug-induced liver injury detection
iCell Hepatocytes 2.0 are readily available and widely used for cytotoxicity testing, enabling the detection of drug-induced liver injury (DILI) at early stages.
- Highly pure populations of >95% hepatocytes
- Able to detect metabolic and immune-mediated hepatotoxicity
- Genotyped for >1,900 ADME markers across >200 genes
Functional model for drug-induced neuronal disruption
These human GABAergic (inhibitory) neurons exhibit spontaneous electrical activity, allowing early detection of adverse effects on neuronal electrophysiology and biochemistry.
- Homogenous populations of >95% human cortical neurons
- Express relevant therapeutic targets and pathways
- Model cell for botulinum neurotoxin (BoNT) potency assay
- Optimized post-thaw recovery and ≥2 weeks viability
Highly predictive model of drug-induced seizures
The rapid formation of spontaneously active neural networks and functional synapses makes these glutamatergic (excitatory) neurons suitable for predicting seizurogenic toxicity.
- Highly pure populations of ≥90% glutamatergic neurons
- Compatible with multielectrode array (MEA) and electrophysiology
- Model drug-induced calcium signaling disruption
- Assay-ready and viable for ≥4 weeks in culture
Relevant neurological immune cells for cytotoxicity testing
These human microglial cells consistently express microglial markers, including IBA1 and TREM2, enhancing the relevance of safety pharmacology and toxicology screening.
- Highly pure populations of >80% functional microglia
- Capable of phagocytosis and cytokine signaling
- Disease models available, including Alzheimer’s disease
Relevant, Reliable, and Scalable
Fuel safety pharmacology with batch-to-batch consistency
Our rigorous quality control processes ensure consistent cell performance for reproducible results.
Large-scale production underlies a dependable supply of our iPSC-derived cell lines, supporting high-throughput toxicology screening and eliminating study disruption.
Increase biological relevance of in vitro toxicity testing
With our isogenic cell lines, you can co-culture compatible products in 2D, 3D, or organ-on-a-chip formats, improving the physiological significance of your cytotoxicity testing.
Need More Information?
Explore our expansive protocol libraries
Access detailed technical information and protocols to support your in vitro toxicity testing.
From co-culturing cardiac cells to promoting neurite outgrowth, FUJIFILM CDI provides thorough documentation to advance your drug safety assessments.
Browse helpful resources
Need help finding the right cell line?
Our team of experts is ready to help you find what you need for your safety pharmacology and cytotoxicity testing.
Make in vitro toxicity testing relevant and reproducible
Achieve consistent, translational results with human-derived iPSCs that faithfully reflect native morphology and functionality.
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