As a leader in stem cell technology, cell culture, and research reagents, FUJIFILM Cellular Dynamics (FCDI) is dedicated to furthering innovation. That's why FCDI never stops developing and supplying critical research tools and materials to life science researchers, ultimately leading to drug discovery, and helping to make the world a healthier place.
Disease Modeling/Drug Discovery
Disease modeling using human induced pluripotent stem cells (hiPSCs) for understanding the molecular basis and mechanisms of human diseases has unlocked new possibilities for drug discovery. The availability of donor-specific iPS cells, coupled with gene-editing techniques and genome-wide association studies (GWAS), provide a powerful in vitro disease modeling system amenable for drug development and screening studies. These iPSC-derived iCell® products can be used for:
- Innate Disease Modeling: Models generated from donors with specific disease genotypes
- Engineered Disease Modeling: Apparently healthy normal donor iPSCs genome engineered to introduce a disease-specific mutation
- Induced Disease Modeling: Using cell culture conditions to invoke a disease state response
Toxicology/Safety Pharmacology
Toxicity testing and safety pharmacology requires physiologically relevant human cells for the development of in vitro studies that better predict toxicity. iPSC-derived cardiomyocytes are being used for predicting drug-induced cardiac arrhythmia, while iPSC-derived neural cells are being used to assess neurotoxicity of drug candidates. These cells provide:
- Biologically and physiologically relevant human cell models
- Highly pure cell types
- Consistency between batches to provide highly reproducible results
Potency Testing & Applied Markets
iCell products have proven to be effective alternatives to animal models for development, manufacturing and potency testing of pharmaceutical compounds. For example, iCell GABANeurons have been applied to the assay of therapeutic-grade botulinum toxin permitting substantial cost savings and a more humane approach to potency testing.
- Relevant human cells present viable alternatives to animal models
- Custom batch manufacturing available for large scale applications
- Consistency between batches to provide highly reproducible results
FUJIFILM Life Sciences
Fujifilm brings continuous innovation and leading-edge products to provide solutions to the evolving needs for a broad spectrum of industries across healthcare functions. The diverse life science business from Fujifilm offers expertise and technologies for regenerative medicine, biopharmaceutical contract development and manufacturing, cell culture media and drug formulation.
- FUJIFILM Irvine Scientific, Learn More
- FUJIFILM Wako Pure Chemical, Learn More
- FUJIFILM Diosynth Biotechnologies, U.S.A., Inc., Learn More
- FUJIFILM VisualSonics, Inc., Learn More
