Drive Rapid and Reliable Insights with iPSC Disease Modeling
More relevant disease models will advance mechanistic understanding and drive drug development. While traditional models have provided valuable insights, challenges surrounding model availability, reproducibility, and species differences limit their utility and translatability.
With the option to generate cellular disease models from donor cohorts and a diverse iPSC bank containing healthy and diseased genotypes, iCell® disease models support robust and relevant in vitro disease modeling studies.
iPSC Disease Models Bridge the Gap Between Bench and Bedside
With relevance, flexibility, and speed
Overcome issues of limited biological relevance by co-culturing or integrating compatible cell lines into microphysiological systems, and be confident in your results with isogenic controls. FUJIFILM CDI’s readily available cellular disease models are highly pure, terminally differentiated, and ready to thaw, plate, and assay.
Develop Robust Cell Lines for iPSC Disease Modeling
Create models from donors with disease genotypes
iPSCs are generated from donors with specific disease genotypes of interest and differentiated into relevant cell types.
- Define the genotype of interest and select donor(s) for iPSC generation
- Differentiate iPSCs into any cell type found in the adult body
Introduce disease-specific mutations with gene editing
Donor iPSCs with apparently healthy normal (AHN) phenotypes undergo gene editing to create iPSC disease models.
- Use licensed engineering methods, including CRISPR, TALEN, and ZFNs
- Modify iPSC genomes with knock-ins, knock-outs, SNPs, and reporters
Use exogenous stimuli to induce disease states
Differentiated AHN human iPSC-derived cell types are exposed to disease-inducing culture conditions.
- Model epilepsy in iCell neural cell lines with pro-seizurogenic compounds
- Model Alzheimer’s disease in iCell GABANeurons with Aβ1-42 peptide addition
- Use healthy isogenic controls to enable robust comparisons
Elevate Your Research with our Cardiac iPSC Disease Models
Consistent, relevant, and scalable
We combine industrial-scale production with strict quality control processes to ensure a reliable supply of >90% pure cardiomyocytes.
Ready-from-thaw, our cardiac disease models exhibit the relevant morphology and functionality to reflect disease endpoints faithfully.
Healthy isogenic controls are available for all iCell cardiac cellular disease models, ensuring robust and efficient disease modeling to advance research and preclinical studies.
Browse cardiac iPSC disease models
Explore neurological disorders with relevant in vitro models
Diverse, reliable, and versatile
Our readily available neural cellular disease models encompass a wide range of disease genotypes to support relevant and flexible neurological disease and neurodegeneration modeling.
We can also generate custom neural iPSC disease models using your donor cells, banked iPSCs, or alternate cell types with our current models.
As with all iCell disease models, isogenic controls and rigorous quality control processes support robust research and accurate data.
Browse neural iPSC disease models
Need help finding the right iPSC disease model?
Our team of experts is ready to help you find what you need to fuel relevant and reliable iPSC disease modeling.
Accurately model human diseases
Increase biological relevance and enhance the translational value of your cellular disease models with iPSCs that capture native morphology, function, and disease endpoints.
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